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616379 Toxin A, Clostridium difficile - Calbiochem

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Synonyme: Enterotoxin

616379
  
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      Description
      Overview

      This product has been discontinued.



      A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, leading to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositol 4,5-bisphosphate. Unlike Exoenzyme C3 (Cat. No. 341208), this toxin does not require assistance to permeabilize cells.
      Catalogue Number616379
      Brand Family Calbiochem®
      SynonymsEnterotoxin
      References
      ReferencesMackay, D.J. and Hall, A. 1998. J. Biol. Chem. 273, 20685.
      Mahida, Y.R., et al. 1996. Gut 38, 337.
      Wilkins, T.D. and Lyerly, D.M. 1996. Trends Microbiol. 4, 49.
      Product Information
      ATP CompetitiveN
      FormSolid
      FormulationLyophilized from 50 mM Tris, 50 mM NaCl, 0.1% trehalose, pH 7.5.
      ReversibleN
      Quality LevelMQ100
      Biological Information
      Biological activityBinds to fresh rabbit red blood cells in a hemagglutination assay. Cytotoxic as determined by a cell rounding assay using human foreskin cells
      Primary TargetSmall GTPases, such as Rho, Rac, and Cdc42
      PuritySingle band by SDS-PAGE
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSKA8080200
      Safety Information
      R PhraseR: 26/27/28-36/37/38

      Very toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 week at 4°C. Toxin A activity was found to decrease to 1/10 after one week storage at 4°C following reconstitution.
      Global Trade Item Number
      Bestellnummer GTIN
      616379 0