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614320 Toll-Like Receptor 7 Ligand II

Toll-Like Receptor 7 Ligand II: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine, 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      226907-52-4C₁₅H₁₇N₅O₃
      Description
      Overview

      This product has been discontinued.





      A cell-permeable hydroxyadenine compound that acts as a potent and highly specific TLR7 (toll-like receptor 7) agonist without any detectable activity towards TLR2/3/5/8/9. Shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures in vitro and exhibit excellent oral bioavailability in mice in vivo with ~100-fold higher plasma IFN-inducing activity than Imiquimoid (Cat. No. 401020).
      Catalogue Number614320
      Brand Family Calbiochem®
      Synonyms9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine, 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
      References
      ReferencesJin, G., et al. 2006. Bioorg. Med. Chem. 16, 4559.
      Lee, J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1828.
      Kurimoto, A., et al. 2004. Bioorg. Med. Chem. 12, 1091.
      Product Information
      CAS number226907-52-4
      FormWhite solid
      Hill FormulaC₁₅H₁₇N₅O₃
      Chemical formulaC₁₅H₁₇N₅O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      614320 0

      Documentation

      Toll-Like Receptor 7 Ligand II Analysenzertifikate

      TitelChargennummer
      614320

      Literatur

      Übersicht
      Jin, G., et al. 2006. Bioorg. Med. Chem. 16, 4559.
      Lee, J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1828.
      Kurimoto, A., et al. 2004. Bioorg. Med. Chem. 12, 1091.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine, 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
      DescriptionA cell-permeable hydroxyadenine compound that acts as a potent and highly specific TLR7 (toll-like receptor 7) agonist without any detectable activity towards TLR2/3/5/8/9. Shown to be 10-times more potent than R848 in stimulating the production of TLR7-dependent cytokines in cultures in vitro and exhibit excellent oral bioavailability in mice in vivo with ~100-fold higher plasma IFN-inducing activity than Imiquimoid (Cat. No. 401020).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number226907-52-4
      Chemical formulaC₁₅H₁₇N₅O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesJin, G., et al. 2006. Bioorg. Med. Chem. 16, 4559.
      Lee, J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 1828.
      Kurimoto, A., et al. 2004. Bioorg. Med. Chem. 12, 1091.