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612085 Tie2 Kinase Inhibitor - CAS 948557-43-5 - Calbiochem

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Synonyme: 4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      948557-43-5C₂₆H₂₁N₃O₂S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pyridinylimidazole compound that acts as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2 (IC50 = 250 nM) with ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1β. Shown to exhibit antiangiogenesis activity in a Matrigel assay (70% reduction, 50 mg/kg/0.5 day, i.p.) and inhibit the growth of xenografted tumor (no apparent growth up to 20 days, 25 mg/kg/0.5 day, i.p.) in mice in vivo.
      Catalogue Number612085
      Brand Family Calbiochem®
      Synonyms4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
      References
      ReferencesSemones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.
      Product Information
      CAS number948557-43-5
      FormOrange-tan solid
      Hill FormulaC₂₆H₂₁N₃O₂S
      Chemical formulaC₂₆H₂₁N₃O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      612085 0

      Documentation

      Tie2 Kinase Inhibitor - CAS 948557-43-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      612085

      Literatur

      Übersicht
      Semones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-May-2011 RFH
      Synonyms4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
      DescriptionA cell-permeable pyridinylimidazole compound that acts as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2 (IC50 = 250 nM) with ~200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1β. Shown to exhibit antiangiogenesis activity in a Matrigel assay (70% reduction, 50 mg/kg/0.5 day, i.p.) and inhibit the growth of xenografted tumor (no apparent growth up to 20 days, 25 mg/kg/0.5 day, i.p.) in mice in vivo.
      FormOrange-tan solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number948557-43-5
      Chemical formulaC₂₆H₂₁N₃O₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSemones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.