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655203 TX-1918 - CAS 503473-32-3 - Calbiochem

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Key Spec Table

CAS #Empirical Formula
503473-32-3C₁₄H₁₂O₃

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655203-10MG
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      Kst.-Ampulle 10 mg
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      Description
      OverviewA cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eEF2-K (IC50 = 440 nM), while it inhibits other kinases at much higher concentrations (IC50 = 4.4, 44, 44, and 440 µM for Src, PKA, PKC, and EGFR-K, respectively). Displays potent antitumor activity (EC50 = 2.07 and 230 µM in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥5000-fold) and hepato-toxicity (≥90-fold) when compared with another tyrphostin, AG 17 (Cat. No. 658425). It is therefore a more promising candidate as a therapeutic agent for cancer treatment.
      Catalogue Number655203
      Brand Family Calbiochem®
      Synonyms2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
      References
      ReferencesHori, H., et al. 2002. Bioorg. Med. Chem. 10, 3257.
      Product Information
      CAS number503473-32-3
      ATP CompetitiveN
      FormLight orange solid
      Hill FormulaC₁₄H₁₂O₃
      Chemical formulaC₁₄H₁₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargeteEF2-K
      Primary Target IC<sub>50</sub>440 nM against eEF2-K
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      655203-10MG 04055977184716