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SCC177 TS/A Mouse Mammary Adenocarcinoma Cell Line

TS/A mouse mammary adenocarcinoma cell line is a well characterized and highly published model for breast cancer research.

TS/A Mouse Mammary Adenocarcinoma Cell Line: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Key Applications: Cell Culture
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SCC177
≥1X10⁶ cells/vial  
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      Übersicht

      Replacement Information

      Key Spec Table

      Key Applications
      CULT
      Description
      Catalogue NumberSCC177
      DescriptionTS/A Mouse Mammary Adenocarcinoma Cell Line
      OverviewThe TS/A cell line was isolated from a mammary adenocarcinoma that arose spontaneously in a BALB/c female mouse (1). TS/A is a highly metastatic mouse mammary adenocarcinoma cell line exhibiting a marked degree of morphological heterogeneity in culture, with a range of differentiated cell types from epithelial-like to fibroblast-like (1). TS/A cells express estrogen receptor and colony-stimulating factor and are negative for the adhesion protein ICAM-1 (2,3).

      The TS/A cell line is a well-characterized and highly published model for tumor metastasis and heterogeneity and is a popular tool for studies of immunological gene therapy (4,5). It may also be used as a syngeneic mouse model of breast cancer. The main biological features of the TS/A model system have recently been reviewed, including in depth discussion of tumor–host interactions and experimental gene therapy (De Giovanni, Carla, et al. "Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model." Cancers 11.12 (2019): 1889).
      Alternate Names
      • TSA
      Background InformationMetastasizing (stage IV) breast cancers have the lowest survival rate among all stages of breast cancer. Metastases may take on a range of morphologies in their new locations, complicating diagnosis and decisions on courses of treatment. Tumor cell lines that mimic the in vivo behavior of metastasizing cancers are thus critical tools in breast cancer research.

      References:
      1. Clin Exp Metastasis 1983; 1(4): 373-380.
      2. Br J Cancer 1985; 52(2): 215-222.
      3. Eur J Immunol 1995; 25(5): 1154-1162.
      4. Lab Invest 1996; 74(1): 146-157.
      5. Cancer Res 1994; 54: 6022-6026.
      References
      Product Information
      Applications
      ApplicationTS/A mouse mammary adenocarcinoma cell line is a well characterized and highly published model for breast cancer research.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      SCC177 04054839573743