614305 Sigma-AldrichTLR1/TLR2 Antagonist, CU-CPT22 - Calbiochem
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Übersicht
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Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 614305-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable benzotropolone compound that competes against Pam3CSK4- (Cat. No. 506350) for TLR1/TLR2 heterodimer binding (Ki = 410 nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580 nM) without apparent cytotoxicity ( up to 100 µM and 24 h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5 µM and little inhibitory potency against a panel of 10 kinases at 5 µM (by <11% inhibition). |
| Catalogue Number | 614305 |
| Brand Family | Calbiochem® |
| Synonyms | Hexyl-3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate |
| References | |
|---|---|
| References | Cheng, K., et al. 2012. Angew. Chem. Int. Ed. 51, 12246. |
| Product Information | |
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| Form | Orange solid |
| Hill Formula | C₁₉H₂₂O₇ |
| Chemical formula | C₁₉H₂₂O₇ |
| Reversible | Y |
| Structure formula Image | |
| Applications |
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| Biological Information | |
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| Primary Target | TLR1 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 614305-10MG | 04055977186611 |
Documentation
TLR1/TLR2 Antagonist, CU-CPT22 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 614305 |
Literatur
| Übersicht |
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| Cheng, K., et al. 2012. Angew. Chem. Int. Ed. 51, 12246. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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