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574662 Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem

The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.

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Synonyme: Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor

Primary Target: Interleukin enhancer-binding factor 3 (ILF3/NF110)
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      781661-94-7C₂₀H₁₉BrN₄O₃
      Description
      OverviewA cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
      Catalogue Number574662
      Brand Family Calbiochem®
      SynonymsSurvivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
      References
      ReferencesNakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
      Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
      Nakahara, T., et al. 2007, Cancer Res. 67, 8014.
      Product Information
      CAS number781661-94-7
      FormYellow solid
      Hill FormulaC₂₀H₁₉BrN₄O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target Interleukin enhancer-binding factor 3 (ILF3/NF110)
      Primary Target IC<sub>50</sub>540nM
      Secondary targetUnknown
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      574662 0

      Documentation

      Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      574662

      Literatur

      Übersicht
      Nakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
      Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
      Nakahara, T., et al. 2007, Cancer Res. 67, 8014.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-March-2017 JSW
      SynonymsSurvivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
      DescriptionA cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number781661-94-7
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
      Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
      Nakahara, T., et al. 2007, Cancer Res. 67, 8014.