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569615 Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem

The Stem-Cell Factor/c-Kit Inhibitor, ISCK03, also referenced under CAS 945526-43-2, controls the biological activity of Stem-Cell Factor/c-Kit. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: 4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      945526-43-2C₁₉H₂₁N₃O₂S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 µM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 µM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells. Oral administration of ISCK03 is shown to induce hair depigmentation in C57BL/6 mice in a dose-dependent and reversible manner. Topical application is likewise demonstrated to decrease UV-induced pigmentation and epidermal melanin level in Brownish guinea pigs in vivo.
      Catalogue Number569615
      Brand Family Calbiochem®
      Synonyms4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II
      References
      ReferencesNa, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.
      Product Information
      CAS number945526-43-2
      FormDark yellow solid
      Hill FormulaC₁₉H₂₁N₃O₂S
      Chemical formulaC₁₉H₂₁N₃O₂S
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      569615 0

      Documentation

      Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      569615

      Literatur

      Übersicht
      Na, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II
      DescriptionA cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 µM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 µM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells. Oral administration of ISCK03 is shown to induce hair depigmentation in C57BL/6 mice in a dose-dependent and reversible manner. Topical application is likewise demonstrated to decrease UV-induced pigmentation and epidermal melanin level in Brownish guinea pigs in vivo.
      FormDark yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number945526-43-2
      Chemical formulaC₁₉H₂₁N₃O₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNa, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.