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567805 Src Kinase Inhibitor I - CAS 179248-59-0 - Calbiochem

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Synonyme: 4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII

Primary Target: Src
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      179248-59-0C₂₂H₁₉N₃O₃
      Description
      Overview

      This product has been discontinued.



      A 4′-phenoxy substituted 4-anilinoquinazoline compound that acts as a potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src family tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 µM and 30 µM, respectively).
      Catalogue Number567805
      Brand Family Calbiochem®
      Synonyms4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII
      References
      ReferencesTian, G., et al. 2001. Biochemistry 40, 7084.
      Product Information
      CAS number179248-59-0
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₂H₁₉N₃O₃
      Chemical formulaC₂₂H₁₉N₃O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSrc
      Primary Target IC<sub>50</sub>44 nM and 88 nM for Src and Lck, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      567805 0

      Documentation

      Src Kinase Inhibitor I - CAS 179248-59-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      567805

      Literatur

      Übersicht
      Tian, G., et al. 2001. Biochemistry 40, 7084.

      Literaturstellen

      Titel
    • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms4-(4ʹ-Phenoxyanilino)-6,7-dimethoxyquinazoline, VEGFR Tyrosine Kinase Inhibitor XV, VEGFR2 Kinase Inhibitor XIII
      DescriptionA potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 µM, respectively).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number179248-59-0
      Chemical formulaC₂₂H₁₉N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTian, G., et al. 2001. Biochemistry 40, 7084.
      Citation
    • Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.
      		•