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567741 Sphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem

Sphingosine Kinase 1 Inhibitor II, PF-543, CAS 1415562-82-1, is a cell-permeable, competitive inhibitor of sphingosine kinase-1/SphK1-catalyzed sphingosine phosphorylation (IC50 = 2.0 nM).

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Synonyme: (R)-(1-(4-((3-Methyl-5-(phenylsulfonylmethyl)phenoxy)methyl)benzyl)-pyrrolidin-2-yl)methanol, Sphingosine Kinase Inhibitor II, SK Inhibitor II

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567741
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567741-5MG
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      Description
      OverviewA cell-permeable hydroxymethylpyrrolidine compound that inhibits sphingosine kinase-1/SphK1-catalyzed Sphingosine phosphorylation (IC50 = 2.0 nM; [sphingosine] = 3 µM) in a reversible and sphingosine-competitive manner (Ki = 3.6 nM), exhibiting no affinity toward S1P receptors and much reduced inhibitory activity against Sphk2 (6.8% inhibition at 10 µM) or 46 other lipid and portein kinases (IC50 >10 µM). Effectively depletes cellular S1P (by 90% with 1 h 200 nM or 7 d 1 µM drug exposure in 1483 cultures) with concomitant elevation of sphingosine level and no detectable cytotoxicity.
      Catalogue Number567741
      Brand Family Calbiochem®
      Synonyms(R)-(1-(4-((3-Methyl-5-(phenylsulfonylmethyl)phenoxy)methyl)benzyl)-pyrrolidin-2-yl)methanol, Sphingosine Kinase Inhibitor II, SK Inhibitor II
      References
      ReferencesSchnute, M.E., et al. 2012. Biochem. J. 444, 79.
      Product Information
      CAS number1415562-82-1
      EC number465.6
      FormOff-white solid
      Hill FormulaC₂₇H₃₁NO₄S
      Chemical formulaC₂₇H₃₁NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSphingosine Kinase 1 Inhibitor II, PF-543, CAS 1415562-82-1, is a cell-permeable, competitive inhibitor of sphingosine kinase-1/SphK1-catalyzed sphingosine phosphorylation (IC50 = 2.0 nM).
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      567741-5MG 04055977190922