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559307 Sangivamycin - CAS 18417-89-5 - Calbiochem

Sangivamycin - CAS 18417-89-5 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 7-Deaza-7-carbamoyladenosine, NSC-65346

Primary Target: PKC
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      18417-89-5C₁₂H₁₅N₅O₅
      Description
      Overview

      This product has been discontinued.



      A cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.
      Catalogue Number559307
      Brand Family Calbiochem®
      Synonyms7-Deaza-7-carbamoyladenosine, NSC-65346
      References
      ReferencesGreene, N.M., et al. 1995. J. Biol. Chem. 270, 6710.
      Osada, H., et al. 1989. J. Antibiot. 42, 402.
      Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
      Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.
      Product Information
      CAS number18417-89-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₂H₁₅N₅O₅
      Chemical formulaC₁₂H₁₅N₅O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>10 µM against PKC
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUY9355000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      559307 0

      Documentation

      Sangivamycin - CAS 18417-89-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      559307

      Literatur

      Übersicht
      Greene, N.M., et al. 1995. J. Biol. Chem. 270, 6710.
      Osada, H., et al. 1989. J. Antibiot. 42, 402.
      Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
      Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      Synonyms7-Deaza-7-carbamoyladenosine, NSC-65346
      DescriptionA cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.
      FormWhite solid
      CAS number18417-89-5
      RTECSUY9355000
      Chemical formulaC₁₂H₁₅N₅O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Solubility0.1 M KOH (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Highly Toxic
      ReferencesGreene, N.M., et al. 1995. J. Biol. Chem. 270, 6710.
      Osada, H., et al. 1989. J. Antibiot. 42, 402.
      Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
      Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.