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573126 STAT3 Inhibitor XI, STX-0119 - CAS 851095-32-4 - Calbiochem

The STAT3 Inhibitor XI, STX-0119 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide

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573126
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
851095-32-4C₂₂H₁₄N₄O₃

Preis & Verfügbarkeit

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573126-25MG
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      		 Glasflasche 25 mg
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      Description
      OverviewA cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100 µM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.).
      Catalogue Number573126
      Brand Family Calbiochem®
      SynonymsN-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
      References
      ReferencesAshizawa, T., et al. 2011. Int. J. Oncol. 38, 1245,
      Matsuno, K., et al. 2010. ACS Med. Chem. Lett. 1, 371.
      Product Information
      CAS number851095-32-4
      FormGreyish to off-white solid
      Hill FormulaC₂₂H₁₄N₄O₃
      Chemical formulaC₂₂H₁₄N₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      573126-25MG 04055977266078

      Documentation

      STAT3 Inhibitor XI, STX-0119 - CAS 851095-32-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      573126

      Literatur

      Übersicht
      Ashizawa, T., et al. 2011. Int. J. Oncol. 38, 1245,
      Matsuno, K., et al. 2010. ACS Med. Chem. Lett. 1, 371.

      Technische Informationen

      Titel
      JAK/STAT Signaling Research Focus
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-October-2012 JSW
      SynonymsN-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
      DescriptionA cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity in nuclear extract from IL-6-stimulated MDA-MB-468 cells (by 74% at 50 µM) and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 50% and 99%, respectively, at 74 and 100 µM), as well as inhibit the expression of STAT3 target genes, c-myc, cyclin D1, and survivin, both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.).
      FormGreyish to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number851095-32-4
      Chemical formulaC₂₂H₁₄N₄O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Toxicity Standard Handling
      ReferencesAshizawa, T., et al. 2011. Int. J. Oncol. 38, 1245,
      Matsuno, K., et al. 2010. ACS Med. Chem. Lett. 1, 371.