538356 Sigma-AldrichSRPIN803 - Calbiochem
A cell-potent, bioactive, anti-angiogenic dual inhibitor of CK2 & SRPK1. Down-regulates inflammation-associated genes and inhibits choroidal neovascularization in a mouse model of AMD.
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Synonyme: 6-(4-Hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7(6H)-one, SRPK1 Inhibitor II, Casein Kinase II Inhibitor XIII
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Übersicht
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Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 5.38356.0001 |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable, bioavailable, non-toxic thiadiazolopyrimidinone based compound that acts a potent, reversible and ATP-competitive dual inhibitor of CK2 & SRPK1 (IC50 = 0.2 & 2.4 µM, respectively). Displays excellent selectivity in a 306-kinase panel (% inhibition at 10 µM = 82.5, 70.9, 59.9 & 13.7 for CK2α1/β, CK2α2/β, SRPK1 & SRPK2, respectively). Synergistically suppresses VEGF production in a time and dose-dependent manner and down-regulates several angiogenesis genes expression (10 µM in ARPE-19 cells). Shown to be highly efficacious than SRPIN340 (Cat. No. 504293) and significantly inhibit choroidal neovascularization in a mouse model of age-related macular degeneration (intravitreous injection or topical administration). Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 538356 |
| Brand Family | Calbiochem® |
| Synonyms | 6-(4-Hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7(6H)-one, SRPK1 Inhibitor II, Casein Kinase II Inhibitor XIII |
| Description | SRPIN803 |
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| References | Morooka, S., et al. 2015. Mol. Pharmacol. 88, 316. |
| Product Information | |
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| Form | Yellow solid |
| Hill Formula | C₁₄H₉F₃N₄O₃S |
| Chemical formula | C₁₄H₉F₃N₄O₃S |
| Reversible | Y |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | CK2, SRPK1 |
| Primary Target IC<sub>50</sub> | 0.2 & 2.4 µ |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5.38356.0001 | 04054839119460 |
Documentation
SRPIN803 - Calbiochem SDB
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Literatur
| Übersicht |
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| Morooka, S., et al. 2015. Mol. Pharmacol. 88, 316. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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