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573117 SMC Proliferation Inhibitor-2w

The SMC Proliferation Inhibitor-2w, also referenced under CAS 343783-87-9, inhibits the proliferation of human coronary artery smooth muscle cells.

SMC Proliferation Inhibitor-2w: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: N-(3ʹ,4ʹ,5ʹ,-Trimethoxybenzoyl)-(3,4-dimethoxy)ethylanthranilate

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      343783-87-9C₂₁H₂₅NO₈
      Description
      Overview

      This product has been discontinued.





      A diaryl amide analog that exhibits about 15 fold greater selectivity in inhibiting the proliferation of human coronary artery smooth muscle cells (IC50 = 310 nM) over the endothelial cells (IC50 = 4.6 µM). Exhibits over 80-fold greater potency than Tranilast (Cat. No. 616400).
      Catalogue Number573117
      Brand Family Calbiochem®
      SynonymsN-(3ʹ,4ʹ,5ʹ,-Trimethoxybenzoyl)-(3,4-dimethoxy)ethylanthranilate
      References
      ReferencesOgita, H., et al. 2001. Bioorg. Med. Chem. Lett. 11, 549.
      Product Information
      CAS number343783-87-9
      FormOff-white solid
      Hill FormulaC₂₁H₂₅NO₈
      Chemical formulaC₂₁H₂₅NO₈
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      573117 0

      Documentation

      SMC Proliferation Inhibitor-2w Analysenzertifikate

      TitelChargennummer
      573117

      Literatur

      Übersicht
      Ogita, H., et al. 2001. Bioorg. Med. Chem. Lett. 11, 549.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsN-(3ʹ,4ʹ,5ʹ,-Trimethoxybenzoyl)-(3,4-dimethoxy)ethylanthranilate
      DescriptionA diarylamide derivative that exhibits about 15-fold greater selectivity in inhibiting the proliferation of human coronary artery smooth muscle cells (SMCs) (IC50 = 310 nM) compared to endothelial cells (IC50 = 4.6 µM). Exhibits ~80-fold greater potency than Tranilast (Cat. No. 616400) in inhibition of PDGF-induced proliferation of SMCs.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number343783-87-9
      Chemical formulaC₂₁H₂₅NO₈
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesOgita, H., et al. 2001. Bioorg. Med. Chem. Lett. 11, 549.