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567733 S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

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Synonyme: Sphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871

Primary Target: S1P1 Receptor
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      256414-75-2C₂₀H₁₀F₆N₂OS
      Description
      Overview

      This product has been discontinued.



      A cell-permeable oxadiazolothienyl compound that acts as a potent and highly selective S1P1 agonist (EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively). Shown to induce S1P1-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED50 = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P2-5, even at concentrations as high as 10 µM.
      Catalogue Number567733
      Brand Family Calbiochem®
      SynonymsSphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871
      References
      ReferencesSanna, M.G., et al. 2004. J. Biol. Chem. 279, 13839.
      Product Information
      CAS number256414-75-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₁₀F₆N₂OS
      Chemical formulaC₂₀H₁₀F₆N₂OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetS1P1 Receptor
      Primary Target IC<sub>50</sub>EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      567733 0

      Documentation

      S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      567733

      Literatur

      Übersicht
      Sanna, M.G., et al. 2004. J. Biol. Chem. 279, 13839.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-April-2008 RFH
      SynonymsSphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871
      DescriptionA cell-permeable, potent, and highly selective S1P1 agonist (EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively). Shown to induce S1P1-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED50 = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P2-5, even at concentrations as high as 10 µM.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number256414-75-2
      Chemical formulaC₂₀H₁₀F₆N₂OS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSanna, M.G., et al. 2004. J. Biol. Chem. 279, 13839.