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509707 (S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem

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Synonyme: (S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine

Primary Target: GluK1
509707
  
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      140187-25-3C₇H₈IN₃O₄
      Description
      Overview

      This product has been discontinued.



      A potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC50 = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC50 = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509707
      Brand Family Calbiochem®
      Synonyms(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
      References
      ReferencesBhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
      Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
      Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
      Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.
      Product Information
      CAS number140187-25-3
      FormWhite solid
      Hill FormulaC₇H₈IN₃O₄
      Chemical formulaC₇H₈IN₃O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGluK1
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      509707 0

      Documentation

      (S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Bhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
      Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
      Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
      Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-February-2014 JSW
      Synonyms(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
      DescriptionA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC50 = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC50 = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number140187-25-3
      Chemical formulaC₇H₈IN₃O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Solubility1N NaOH (25 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
      Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
      Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
      Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.