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505724 Rotigotine Hydrochloride - CAS 125572-93-2 - Calbiochem

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Synonyme: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2­-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride, Dopamine Receptor Agonist, Rotigotine Hydrochloride, Neupro

Primary Target: D3
505724
  
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      125572-93-2C₁₉H₂₅NOS•HCl
      Description
      Overview

      This product has been discontinued.



      A highly potent non-ergoline dopamine D2 and D3 receptor agonist (Ki = 13 and 0.71 nM for D2 and D3 respectively). Also displays significant affinity for 5-HT1A and adrenergic α2B receptors. Transdermally used in treatment of Parkinson′s disease and restless legs syndrome.
      Catalogue Number505724
      Brand Family Calbiochem®
      Synonyms(6S)-5,6,7,8-Tetrahydro-6-[propyl[2­-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride, Dopamine Receptor Agonist, Rotigotine Hydrochloride, Neupro
      References
      ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
      Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
      Product Information
      CAS number125572-93-2
      FormWhite solid
      Hill FormulaC₁₉H₂₅NOS•HCl
      Chemical formulaC₁₉H₂₅NOS•HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetD3
      Primary Target K<sub>i</sub>0.71 nM for D3
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      505724 0

      Documentation

      Rotigotine Hydrochloride - CAS 125572-93-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Splinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
      Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms(6S)-5,6,7,8-Tetrahydro-6-[propyl[2­-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride, Dopamine Receptor Agonist, Rotigotine Hydrochloride, Neupro
      DescriptionA highly potent non-ergoline dopamine D2 and D3 receptor agonist (Ki = 13 and 0.71 nM for D2 and D3 respectively). Also displays significant affinity for 5-HT1A and adrenergic α2B receptors. Transdermally used in treatment of Parkinson′s disease and restless legs syndrome.
      FormWhite solid
      CAS number125572-93-2
      Chemical formulaC₁₉H₂₅NOS•HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
      Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.