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557362 Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem

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Synonyme: 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I, (S)-Isomer

Primary Target: p34cdk1/cyclin B kinase
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      186692-45-5C₁₉H₂₆N₆O
      Description
      Overview

      This product has been discontinued.



      The (S)-enantiomer of the potent cyclin-dependent kinase (Cdk) inhibitor Roscovitine (Cat. No. 557360). Potently inhibits p34cdk1/cyclin B kinase (IC50 = 800 nM).
      Catalogue Number557362
      Brand Family Calbiochem®
      Synonyms2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I, (S)-Isomer
      References
      ReferencesHavlicek, L., et al. 1997. J. Med. Chem. 40, 408.
      Product Information
      CAS number186692-45-5
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 6,316,456.
      FormWhite solid
      Hill FormulaC₁₉H₂₆N₆O
      Chemical formulaC₁₉H₂₆N₆O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp34cdk1/cyclin B kinase
      Primary Target IC<sub>50</sub>800 nM against p34cdk1/cyclin B kinase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      557362 0

      Documentation

      Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      557362

      Literatur

      Übersicht
      Havlicek, L., et al. 1997. J. Med. Chem. 40, 408.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I, (S)-Isomer
      DescriptionThe (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (Cat. No. 557360). Potently inhibits p34cdc2/cyclin B kinase (IC50 = 800 nM).
      FormWhite solid
      CAS number186692-45-5
      Chemical formulaC₁₉H₂₆N₆O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHavlicek, L., et al. 1997. J. Med. Chem. 40, 408.