553511 Sigma-AldrichRac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem
The Rac1 Inhibitor II, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Rac1 Inhibitor II, also referenced under CAS 1090893-12-1, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide, Z62954982
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1090893-12-1 | C₂₀H₂₁N₃O₅S |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 553511-10MG |
|
10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). Also available in InSolution™ format (Cat. No. 553512). |
| Catalogue Number | 553511 |
| Brand Family | Calbiochem® |
| Synonyms | 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide, Z62954982 |
| References | |
|---|---|
| References | Ferri, N., et al. 2009. J. Med. Chem. 52, 4087. |
| Product Information | |
|---|---|
| CAS number | 1090893-12-1 |
| Form | Off-white solid |
| Hill Formula | C₂₀H₂₁N₃O₅S |
| Chemical formula | C₂₀H₂₁N₃O₅S |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥93% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 553511-10MG | 04055977193701 |
Documentation
Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem SDB
| Titel |
|---|
Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 553511 |
Literatur
| Übersicht |
|---|
| Ferri, N., et al. 2009. J. Med. Chem. 52, 4087. |