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557354 ROS Inhibitor, YCG063 - CAS 330997-95-0 - Calbiochem

The ROS Inhibitor, YCG063, also referenced under CAS 330997-95-0, controls the biological activity of ROS.

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Synonyme: YCG063 ROS Inhibitor

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      330997-95-0C₁₉H₂₅N₅O₄S
      Description
      OverviewA cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤ 10 µM) in HepG2 and other cells, and suppresses cellular growth (≤ 50 µM) in HUVEC, HeLa, and HCT15 cultures. At ≤ 10 µM, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECs in vitro without obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhage in vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 µM). dose-dependently.
      Catalogue Number557354
      Brand Family Calbiochem®
      SynonymsYCG063 ROS Inhibitor
      References
      ReferencesKim, K.H., et al. 2011. Biochem. Biophys. Res. Commun. 404, 541.
      Product Information
      CAS number330997-95-0
      FormWhite solid
      Hill FormulaC₁₉H₂₅N₅O₄S
      Chemical formulaC₁₉H₂₅N₅O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      557354 0

      Documentation

      ROS Inhibitor, YCG063 - CAS 330997-95-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      ROS Inhibitor, YCG063 - CAS 330997-95-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      557354

      Literatur

      Übersicht
      Kim, K.H., et al. 2011. Biochem. Biophys. Res. Commun. 404, 541.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-August-2011 RFH
      SynonymsYCG063 ROS Inhibitor
      DescriptionA cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤10 µM) in HepG2 and other cells, and suppresses cellular growth (≤50 µM) in HUVEC, HeLa, and HCT15 cultures. At ≤10 µM, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECs in vitro without obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhage in vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 µM) dose-dependently.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number330997-95-0
      Chemical formulaC₁₉H₂₅N₅O₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, K.H., et al. 2011. Biochem. Biophys. Res. Commun. 404, 541.