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557353 RORγ Inverse Agonist, SR2211 - Calbiochem

The RORγ Inverse Agonist, SR2211 controls the biological activity of RORγ.

RORγ Inverse Agonist, SR2211 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₆H₂₄F₇N₃O
      Description
      OverviewA cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor γ (RORg) and acts as a highly selective and inverse agonist (Ki = 105 nM; IC50 ~ 320 nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.
      Catalogue Number557353
      Brand Family Calbiochem®
      Synonyms1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211
      References
      ReferencesKumar, N., et al. 2012. ACS Chem. Biol. 7, 672.
      Product Information
      FormWhite powder
      Hill FormulaC₂₆H₂₄F₇N₃O
      Chemical formulaC₂₆H₂₄F₇N₃O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      557353 0

      Documentation

      RORγ Inverse Agonist, SR2211 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      RORγ Inverse Agonist, SR2211 - Calbiochem Analysenzertifikate

      TitelChargennummer
      557353

      Literatur

      Übersicht
      Kumar, N., et al. 2012. ACS Chem. Biol. 7, 672.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-August-2012 JSW
      Synonyms1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211
      DescriptionA cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor γ (RORg) and acts as a highly selective and inverse agonist (Ki = 105 nM; IC50 ~ 320 nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₂₄F₇N₃O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKumar, N., et al. 2012. ACS Chem. Biol. 7, 672.