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557305 RNAi Enhancer, Enoxacin Sodium Salt - Calbiochem

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₅H₁₆FN₄NaO₃
      Description
      OverviewA fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; Kd = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC50 of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.).
      Catalogue Number557305
      Brand Family Calbiochem®
      Synonyms1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt
      References
      ReferencesMelo, S., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 4394.
      Zhang, Q., et al. 2008. Cell Res. 18, 1077.
      Shan, G., et al. 2008. Nat. Biotechnol. 26, 933.
      Product Information
      FormWhite to off-white solid
      Hill FormulaC₁₅H₁₆FN₄NaO₃
      Chemical formulaC₁₅H₁₆FN₄NaO₃
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      557305 0

      Documentation

      RNAi Enhancer, Enoxacin Sodium Salt - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      RNAi Enhancer, Enoxacin Sodium Salt - Calbiochem Analysenzertifikate

      TitelChargennummer
      557305

      Literatur

      Übersicht
      Melo, S., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 4394.
      Zhang, Q., et al. 2008. Cell Res. 18, 1077.
      Shan, G., et al. 2008. Nat. Biotechnol. 26, 933.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-October-2017 JSW
      Synonyms1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, Na salt, RNA Interference Enhancer, Enoxacin Sodium Salt
      DescriptionA fluoroquinolone antibacterial compound that displays antitumor properties. Shown to bind to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP; Kd = 12.56 µM), enhance RNAi and stimulate miRNA expression. Specifically induces cell-cycle arrest and apoptosis in a panel of 12-cancer cells (EC50 of 124 µM in HCT-116 cells) and suppresses tumor growth in a xenograft mouse model (10 mg/kg, i.p.).
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₁₆FN₄NaO₃
      Purity≥97% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Toxicity Standard Handling
      ReferencesMelo, S., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 4394.
      Zhang, Q., et al. 2008. Cell Res. 18, 1077.
      Shan, G., et al. 2008. Nat. Biotechnol. 26, 933.