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557401 RNA-Editing Ligase 1 Inhibitor, NSC 45208

The RNA-Editing Ligase 1 Inhibitor, NSC 45208 controls the biological activity of RNA-Editing Ligase 1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

RNA-Editing Ligase 1 Inhibitor, NSC 45208: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
      Description
      Overview

      This product has been discontinued.





      A sulfonated azo dye, initially identified by a Trypanosoma burcei RNA-editing ligase 1 (TbREL1) crystal structure-based inhibitor screening, is shown to inhibit TbREL1 activity (IC50 = 1.95 µM) by targeting the enzyme's ATP binding pocket. V1 is less potent against T4 phage RNA ligase 2 and human DNA ligase IIIβ (IC50 = 3.53 and 27.49 µM, respectively).
      Catalogue Number557401
      Brand Family Calbiochem®
      Synonyms4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor
      References
      ReferencesAmaro, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 17278.
      Product Information
      FormDark red solid
      Hill FormulaC₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
      Chemical formulaC₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% based on elemental analysis
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      557401 0

      Documentation

      RNA-Editing Ligase 1 Inhibitor, NSC 45208 Analysenzertifikate

      TitelChargennummer
      557401

      Literatur

      Übersicht
      Amaro, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 17278.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-August-2009 RFH
      Synonyms4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor
      DescriptionA sulfonated azo dye, initially identified by a Trypanosoma burcei RNA-editing ligase 1 (TbREL1) crystal structure-based inhibitor screening, is shown to inhibit TbREL1 activity (IC50 = 1.95 µM) by targeting the enzyme's ATP binding pocket. V1 is less potent against T4 phage RNA ligase 2 and human DNA ligase IIIβ (IC50 = 3.53 and 27.49 µM, respectively).
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
      Structure formulaStructure formula
      Purity≥95% based on elemental analysis
      SolubilityDMSO (10 mg/ml) or H₂O (1 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAmaro, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 17278.