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505881 (R)-(+)-SKF38393 Hydrochloride - CAS 81702-42-3 - Calbiochem

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Synonyme: Dopamine D₁/D₅ Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393

Primary Target: D₁
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505881
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
81702-42-3C16H₁₇NO₂•HCl

Preis & Verfügbarkeit

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5.05881.0001
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      Description
      OverviewA benzazepine derivative that acts as a selective Dopamine D1/D5 receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.
      Catalogue Number505881
      Brand Family Calbiochem®
      SynonymsDopamine D₁/D₅ Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393
      References
      ReferencesTrampus, M. et al. 1993. J. Pharmacol. 235, 83.
      Cooper, S. J. et al. 1990. Psychopharmacol. 100, 182.
      Dubois, A. et al. 1986. Neurosci. 19, 125.
      Kaiser, C. C. et al. 1982. J. Med. Chem. 25, 697.
      Product Information
      CAS number81702-42-3
      FormWhite solid
      Hill FormulaC16H₁₇NO₂•HCl
      Chemical formulaC16H₁₇NO₂•HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetD₁
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.05881.0001 04055977263176

      Documentation

      (R)-(+)-SKF38393 Hydrochloride - CAS 81702-42-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Trampus, M. et al. 1993. J. Pharmacol. 235, 83.
      Cooper, S. J. et al. 1990. Psychopharmacol. 100, 182.
      Dubois, A. et al. 1986. Neurosci. 19, 125.
      Kaiser, C. C. et al. 1982. J. Med. Chem. 25, 697.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2013 JSW
      SynonymsDopamine D₁/D₅ Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393
      DescriptionA benzazepine derivative that acts as a selective Dopamine D1/D5 receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.
      FormWhite solid
      CAS number81702-42-3
      Chemical formulaC16H₁₇NO₂•HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTrampus, M. et al. 1993. J. Pharmacol. 235, 83.
      Cooper, S. J. et al. 1990. Psychopharmacol. 100, 182.
      Dubois, A. et al. 1986. Neurosci. 19, 125.
      Kaiser, C. C. et al. 1982. J. Med. Chem. 25, 697.