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539183 Proteasome Inhibitor VIII, β-Lactam 3 - CAS 870528-53-3 - Calbiochem

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Synonyme: β-Lactam 3

Primary Target: 20S proteasome
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      870528-53-3C₁₁H₁₇ClN₂O₃
      Description
      Overview

      This product has been discontinued.



      A β-lactam analog of Proteasome Inhibitor VII, Antiprotealide (Cat. No. 539179) that acts as a selective and irreversible inhibitor of the 20S proteasome. While the rate of proteasome inhibition is slower than Omuralide (Cat. No. 426102), β-lactam 3 displays prolonged aqueous stability and therefore may be better suited for biological evaluation.
      Catalogue Number539183
      Brand Family Calbiochem®
      Synonymsβ-Lactam 3
      References
      ReferencesHogan, P.C. and Corey, E.J. 2005. J. Am. Chem. Soc. 127, 15386.
      Product Information
      CAS number870528-53-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₁H₁₇ClN₂O₃
      Chemical formulaC₁₁H₁₇ClN₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Target20S proteasome
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      539183 0

      Documentation

      Proteasome Inhibitor VIII, β-Lactam 3 - CAS 870528-53-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      539183

      Literatur

      Übersicht
      Hogan, P.C. and Corey, E.J. 2005. J. Am. Chem. Soc. 127, 15386.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonymsβ-Lactam 3
      DescriptionA β-lactam analog of Proteasome Inhibitor VII, Antiprotealide (Cat. No. 539179) that acts as a selective and irreversible inhibitor of the 20S proteasome. While the rate of proteasome inhibition is slower than Omuralide (Cat. No. 426102), β-lactam 3 displays prolonged aqueous stability and therefore may be better suited for biological evaluation.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number870528-53-3
      Chemical formulaC₁₁H₁₇ClN₂O₃
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityDMSO (10 mg/ml)
      Storage Protect from moisture
      Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Standard Handling
      ReferencesHogan, P.C. and Corey, E.J. 2005. J. Am. Chem. Soc. 127, 15386.