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538925 Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem

Potent vasodilatory prostaglandin produced by the endothelium.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: PGI₂, Prostacyclin

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      61849-14-7C₂₀H₃₁O₅ · Na
      Description
      Overview

      This product has been discontinued.



      Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Exhibits cytoprotective and fibrinolytic properties.
      Catalogue Number538925
      Brand Family Calbiochem®
      SynonymsPGI₂, Prostacyclin
      References
      ReferencesVane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 11.
      Moncada, S., et al. 1979. Pharmacol. Rev. 30, 293.
      Cho, M.J. and Allen, M.A. 1978. Prostaglandins 15, 943.
      Tateson, J.E., et al. 1977. Prostaglandins 13, 389.
      Product Information
      CAS number61849-14-7
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₂₀H₃₁O₅ · Na
      Chemical formulaC₂₀H₃₁O₅ · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInduces vasodilation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      538925 0

      Documentation

      Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      538925

      Literatur

      Übersicht
      Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 11.
      Moncada, S., et al. 1979. Pharmacol. Rev. 30, 293.
      Cho, M.J. and Allen, M.A. 1978. Prostaglandins 15, 943.
      Tateson, J.E., et al. 1977. Prostaglandins 13, 389.

      Broschüre

      Titel
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Bioactive Lipids Technical Bulletin
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-November-2009 JSW
      SynonymsPGI₂, Prostacyclin
      DescriptionPotent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.
      FormCrystalline solid
      CAS number61849-14-7
      Chemical formulaC₂₀H₃₁O₅ · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.
      Toxicity Harmful
      ReferencesVane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 11.
      Moncada, S., et al. 1979. Pharmacol. Rev. 30, 293.
      Cho, M.J. and Allen, M.A. 1978. Prostaglandins 15, 943.
      Tateson, J.E., et al. 1977. Prostaglandins 13, 389.