505206 Sigma-AldrichPhotochromic TrpA1 Channel Activator, Optovin - CAS 348575-88-2 - Calbiochem
A rhodanine-derived, reversible, photoactivated, TrpA1-selective channel activator.
More>> A rhodanine-derived, reversible, photoactivated, TrpA1-selective channel activator. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: (E)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one, PDSP 22594, Transient Receptor Potential A1 Ion Channel Activator I, TrpA1 Channel Activator I
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 348575-88-2 | C₁₅H₁₃N₃OS₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 5.05206.0001 |
|
Glasflasche | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A rhodanine derivative that acts as a reversible, photoactivated (λmax = 415 nm), and highly TrpA1-selective channel activator and enables light-induced primary murine DRG calcium response in a TrpA1-dependent and HC-030031- (Cat. No. 648485) blockable manner, allowing light-induced activation only in hTrpA1-expressing, but not TrpV1- or TrpM8-expressing, HEK293T transfectants. Its in vivo efficacy is demonstrated in light-induced zebrafish motor activity (EC50/ECmax = 2 µM/3 µM) and low power 405 nm laser-induced head twitch response in mice (0.3 µmol Optovin/20 uL DMSO/ear applied atopically). Exhibits little or no inhibitory activity toward hERG or a panel of 50 human and rodent CNS receptors, channels, and transporters. |
| Catalogue Number | 505206 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one, PDSP 22594, Transient Receptor Potential A1 Ion Channel Activator I, TrpA1 Channel Activator I |
| References | |
|---|---|
| References | Kokel, D., et al. 2013, Nat. Chem. Biol. 9, 257. |
| Product Information | |
|---|---|
| CAS number | 348575-88-2 |
| Form | Yellow powder |
| Hill Formula | C₁₅H₁₃N₃OS₂ |
| Chemical formula | C₁₅H₁₃N₃OS₂ |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | TrpA1 |
| Primary Target IC<sub>50</sub> | EC₅₀ = 2µM |
| Purity | ≥95% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 5.05206.0001 | 04055977263428 |
Documentation
Photochromic TrpA1 Channel Activator, Optovin - CAS 348575-88-2 - Calbiochem SDB
| Titel |
|---|
Literatur
| Übersicht |
|---|
| Kokel, D., et al. 2013, Nat. Chem. Biol. 9, 257. |
| Datenblatt | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|