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516854 Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem

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      Übersicht

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      Enzymatic component of the holotoxin. Has both NAD-glycohydrolase and ADP-ribosyltransferase activities. Inhibits neutrophil-mediated inflammation in vivo via its ADP-ribosylation activity. Unable to penetrate cells in the absence of the B oligomer.
      Catalogue Number516854
      Brand Family Calbiochem®
      References
      ReferencesBrito, G.A., et al. 1997. Infect. Immun. 65, 1114.
      Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
      Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
      Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
      Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
      Tamura, M., et al. 1982. Biochemistry 21, 5516.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationLyophilized from 10 mM Tris, 100 µM EDTA, 0.04% CHAPS, pH 8.0.
      ReversibleN
      Applications
      Biological Information
      Primary TargetHas both NAD-glycohydrolase and ADP-ribosyltransferase activities
      PuritySingle major band by SDS-PAGE
      Physicochemical Information
      Cell permeableN
      Contaminants≤0.1% holotoxin by CHO cell assay
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
      Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      516854 0

      Documentation

      Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem Analysenzertifikate

      TitelChargennummer
      516854

      Literatur

      Übersicht
      Brito, G.A., et al. 1997. Infect. Immun. 65, 1114.
      Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
      Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
      Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
      Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
      Tamura, M., et al. 1982. Biochemistry 21, 5516.

      Broschüre

      Titel
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2008 RFH
      DescriptionEnzymatic component of the holotoxin. Has NAD-glycohydrolase activities. Unable to penetrate cells in the absence of the B oligomer.
      FormLyophilized
      FormulationLyophilized from 10 mM Tris, 100 µM EDTA, 0.04% CHAPS, pH 8.0.
      PuritySingle major band by SDS-PAGE
      Contaminants≤0.1% holotoxin by CHO cell assay
      SolubilityReconstitute with 500 µl sterile dH₂O or high ionic buffer.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
      Toxicity Toxic
      ReferencesBrito, G.A., et al. 1997. Infect. Immun. 65, 1114.
      Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
      Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
      Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
      Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
      Tamura, M., et al. 1982. Biochemistry 21, 5516.

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      Kategorien

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Toxins