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530746 Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem

A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its hyperperoxidation activity (IC₅₀ = 23 µM).

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Synonyme: 2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor

Primary Target: Peroxiredoxin
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530746
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
18080-67-6C₁₀H₈Br₂N₂O₂

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      Description
      OverviewA cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530746
      Brand Family Calbiochem®
      Synonyms2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
      References
      ReferencesNguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
      Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
      Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.
      Product Information
      CAS number18080-67-6
      FormYelllowish brown solid
      Hill FormulaC₁₀H₈Br₂N₂O₂
      Chemical formulaC₁₀H₈Br₂N₂O₂
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPeroxiredoxin
      Primary Target IC<sub>50</sub>23 µM for blocking TgPrxII hyperperoxidation activity
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.30746.0001 04055977242942

      Documentation

      Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Nguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
      Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
      Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-June-2014 JSW
      Synonyms2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
      DescriptionA cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.
      FormYelllowish brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number18080-67-6
      Chemical formulaC₁₀H₈Br₂N₂O₂
      Purity≥95% by NMR
      SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
      Toxicity Standard Handling
      ReferencesNguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
      Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
      Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.