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505226 Pancuronium Dibromide - CAS 15500-66-0 - Calbiochem

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Synonyme: 1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide

Primary Target: nAChR
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505226
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
15500-66-0C₃₅H₆₀N₂O₄•Br₂

Preis & Verfügbarkeit

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5.05226.0001
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      Description
      OverviewA highly potent competitive antagonist selective for nAChRs (IC50 = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.
      Catalogue Number505226
      Brand Family Calbiochem®
      Synonyms1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide
      References
      ReferencesLowenick et al., 2001. Eur. J. Pharmacol. 413, 31.
      Melnikov, L., et al., 1999. Gen Pharmacol. 33, 313.
      Maestrone, E., et al., 1994. Br. J. Pharmacol. 111, 283.
      Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol. 335, 367.
      Product Information
      CAS number15500-66-0
      FormOff-white solid
      Hill FormulaC₃₅H₆₀N₂O₄•Br₂
      Chemical formulaC₃₅H₆₀N₂O₄•Br₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetnAChR
      Primary Target IC<sub>50</sub>5.5nM
      Purity≥98% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25-62-63

      Toxic if swallowed.
      Possible risk of impaired fertility.
      Possible risk of harm to the unborn child.
      S PhraseS: 36/37/39-45-46

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      If swallowed, seek medical advice immediately and show this container or label.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.05226.0001 04055977263497

      Documentation

      Pancuronium Dibromide - CAS 15500-66-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Lowenick et al., 2001. Eur. J. Pharmacol. 413, 31.
      Melnikov, L., et al., 1999. Gen Pharmacol. 33, 313.
      Maestrone, E., et al., 1994. Br. J. Pharmacol. 111, 283.
      Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol. 335, 367.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      Synonyms1,1ʹ-(3α,17β-Dihydroxy-2α,5β-androstan-2-β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide
      DescriptionA highly potent competitive antagonist selective for nAChRs (IC50 = 5.5 nM). A very potent non-depolarizing skeletal muscle relaxant but no sedative or analgesic effects.
      FormOff-white solid
      CAS number15500-66-0
      Chemical formulaC₃₅H₆₀N₂O₄•Br₂
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesLowenick et al., 2001. Eur. J. Pharmacol. 413, 31.
      Melnikov, L., et al., 1999. Gen Pharmacol. 33, 313.
      Maestrone, E., et al., 1994. Br. J. Pharmacol. 111, 283.
      Fryer, D., et al., 1987. Naunyn Schmiedebergs Arch. Pharmacol. 335, 367.