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506046 PRMT Inhibitor VII, DB867 - CAS 619334-60-0 - Calbiochem

A cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine

Primary Target: PRMT1
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506046
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
619334-60-0C₁₇H₁₅NO₅

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      Description
      OverviewA cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number506046
      Brand Family Calbiochem®
      Synonyms5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine
      References
      ReferencesXu, J., et al, 2013. Mol. Cell. 51, 1.
      Product Information
      CAS number619334-60-0
      FormYellow solid
      Hill FormulaC₁₇H₁₅NO₅
      Chemical formulaC₁₇H₁₅NO₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPRMT1
      Primary Target IC<sub>50</sub>9 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.06046.0001 04055977262681

      Documentation

      PRMT Inhibitor VII, DB867 - CAS 619334-60-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Xu, J., et al, 2013. Mol. Cell. 51, 1.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2014 JSW
      Synonyms5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine
      DescriptionA cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number619334-60-0
      Chemical formulaC₁₇H₁₅NO₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Solubility10% Aqueous Acetic Acid (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesXu, J., et al, 2013. Mol. Cell. 51, 1.