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529578 PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem

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Synonyme: 2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      1087-07-6C₁₅H₁₂OS₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 µM), while exhibiting little activity against PPM1A even at concentrations as high as 100 µM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 µM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 µM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
      Catalogue Number529578
      Brand Family Calbiochem®
      Synonyms2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I
      References
      ReferencesRayter, S., et al. 2008. Oncogene 27, 1036.
      Product Information
      CAS number1087-07-6
      FormYellow solid
      Hill FormulaC₁₅H₁₂OS₂
      Chemical formulaC₁₅H₁₂OS₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      529578 0

      Documentation

      PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      529578

      Literatur

      Übersicht
      Rayter, S., et al. 2008. Oncogene 27, 1036.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I
      DescriptionA cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 µM), while exhibiting little activity against PPM1A even at concentrations as high as 100 µM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 µM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 µM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1087-07-6
      Chemical formulaC₁₅H₁₂OS₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (1.5 mg/ml); Do Not Warm
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesRayter, S., et al. 2008. Oncogene 27, 1036.