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14-572 PLK3 Protein, active, 10 µg

Active, N-terminal His6-tagged recombinant human Plk3, residues 19-301, for use in Kinase Assays.

PLK3 Protein, active, 10 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-572
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-572M when ordering the 250 µg size.
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      Replacement Information
      Description
      Catalogue Number14-572
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPLK3 Protein, active, 10 µg
      OverviewN-terminal His6-tagged recombinant human Plk3, residues 19-301
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal His6-tagged recombinant human Plk3, residues 19-301, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryCytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.
      Gene Symbol
      • PLK3
      • CNK
      • PLK-3
      • FNK
      • PRK
      Protein TargetPLK3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9H4B4 # Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein.
      SIZE: 646 amino acids; 71629 Da
      SUBUNIT: Binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain.
      SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
      TISSUE SPECIFICITY: Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.
      PTM: Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis (By similarity).
      SIMILARITY: SwissProt: Q9H4B4 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. & Contains 2 POLO box domains. & Contains 1 protein kinase domain.
      Molecular Weight36kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of Casein
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-572M when ordering the 250 µg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-572 04053252335273