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539654 PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem

The PKCβ Inhibitor, also referenced under CAS 257879-35-9, controls the biological activity of PKCβ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: 3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione

Primary Target: PKCβII, βI
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      257879-35-9C₂₄H₂₁N₅O₂
      Description
      Overview

      This product has been discontinued.



      An anilino-monoindolylmaleimide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI) and displays greater selectivity over PKCα, γ,& ε (IC50 = 331 nM, > 1 µM, and 2.8 µM, respectively).
      Catalogue Number539654
      Brand Family Calbiochem®
      Synonyms3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
      References
      ReferencesTanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.
      Product Information
      CAS number257879-35-9
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₂₄H₂₁N₅O₂
      Chemical formulaC₂₄H₂₁N₅O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKCβII, βI
      Primary Target IC<sub>50</sub>5 nM, 21 nM for human PKCβII and βI
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      539654 0

      Documentation

      PKCβ Inhibitor - CAS 257879-35-9 - Calbiochem Analysenzertifikate

      TitelChargennummer
      539654

      Literatur

      Übersicht
      Tanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      Synonyms3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
      DescriptionA potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI, respectively). Displays greater selectivity for PKCβ compared to PKCα, PKCγ,and PKCε (IC50 = 331 nM, >1 µM, and 2.8 µM, respectively).
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number257879-35-9
      Chemical formulaC₂₄H₂₁N₅O₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.