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116805 PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem

The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: Protein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV

Primary Target: PKA
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116805
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
99534-03-9C₉₄H₁₄₈N₃₂O₃₁

Preis & Verfügbarkeit

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116805-500UG
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      		 Kst.-Ampulle 500 μg
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      Description
      OverviewA potent synthetic peptide that is a competitive inhibitor of protein kinase A (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.
      Catalogue Number116805
      Brand Family Calbiochem®
      SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
      References
      ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
      Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
      Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
      Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
      Product Information
      CAS number99534-03-9
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
      Hill FormulaC₉₄H₁₄₈N₃₂O₃₁
      Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
      Hygroscopic Hygroscopic
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKA
      Primary Target K<sub>i</sub>2.3 nM for protein kinase A
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      116805-500UG 04055977208214

      Documentation

      PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem Analysenzertifikate

      TitelChargennummer
      116805

      Literatur

      Übersicht
      Knighton, D.R., et al. 1991. Science 253, 525.
      Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
      Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
      Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
      DescriptionPeptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (Ki = 2.3 nM).
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
      CAS number99534-03-9
      Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
      Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml). Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization.
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
      Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
      Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
      Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.