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524618 PIP3 Antagonist, PITenin-7 - CAS 1356060-65-5 - Calbiochem

The PIP3 Antagonist, PITenin-7 controls the biological activity of PIP3.

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Synonyme: N-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V

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524618
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
1356060-65-5C₂₂H₂₀N₂O₂S

Preis & Verfügbarkeit

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524618-10MG
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      Description
      OverviewA cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC50 = 13.4 and 27.1 µM, respectively) and PDK1 (IC50 = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC50 = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.
      Catalogue Number524618
      Brand Family Calbiochem®
      SynonymsN-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V
      References
      ReferencesMiao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.
      Product Information
      CAS number1356060-65-5
      FormYellow-white semi-solid
      Hill FormulaC₂₂H₂₀N₂O₂S
      Chemical formulaC₂₂H₂₀N₂O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      524618-10MG 04055977197457

      Documentation

      PIP3 Antagonist, PITenin-7 - CAS 1356060-65-5 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      PIP3 Antagonist, PITenin-7 - CAS 1356060-65-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      524618

      Literatur

      Übersicht
      Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2012 JSW
      SynonymsN-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V
      DescriptionA cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC50 = 13.4 and 27.1 µM, respectively) and PDK1 (IC50 = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC50 = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.
      FormYellow-white semi-solid
      CAS number1356060-65-5
      Chemical formulaC₂₂H₂₀N₂O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMiao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.