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14-788M PI3 Kinase (p110β/p85β) Murine, 250 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110β & untagged, recombinant, full length mouse p85β. For use in Kinase Assays.

14-788M
250 µg  Also available in 10 μg size (cat#14-788) and in bulk (cat# 14-788-K).
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      Replacement Information
      Description
      Catalogue Number14-788M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3 Kinase (p110β/p85β) Murine, 250 µg
      OverviewComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110β and untagged, recombinant, full length mouse p85β.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110β & untagged, recombinant, full length mouse p85β. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceCoexpressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryPhosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]
      Gene Symbol
      • PIK3CB
      • DKFZp779K1237
      • PI3K
      • p110-BETA
      • PI3Kbeta
      • MGC133043
      • PIK3C1
      Protein TargetPI3Kβ/p85β
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42338 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
      SIZE: 1070 amino acids; 122762 Da
      SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.
      TISSUE SPECIFICITY: Expressed ubiquitously.
      SIMILARITY: SwissProt: P42338 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
      Molecular Weightp110β MW = 125.5kDa, p85β MW = 81.4kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-788) and in bulk (cat# 14-788-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-788M 04053252509308

      Documentation

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      Bestellnummer Beschreibung  
      14-788 PI3 Kinase (p110β/p85β) Murine, 10 µg Preis & Verfügbarkeit

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      Kategorien

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases