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528114 PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem

The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: 5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      6318-41-8C₁₁H₇NO₄S
      Description
      OverviewA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 µM for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 (Cat. Nos. 440202 & 440204) via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).
      Catalogue Number528114
      Brand Family Calbiochem®
      Synonyms5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
      References
      ReferencesFerrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.
      Product Information
      CAS number6318-41-8
      FormYellow solid
      Hill FormulaC₁₁H₇NO₄S
      Chemical formulaC₁₁H₇NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 43

      May cause sensitization by skin contact.
      S PhraseS: 36/37-45

      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      528114 0

      Documentation

      PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      528114

      Literatur

      Übersicht
      Ferrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, AS041164, PI 3-K Inhibitor VII
      DescriptionA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 µM for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 µM). Exhibits similar pharmacokinetics as LY 294002 (Cat. Nos. 440202 & 440204) via oral administration, but is 3-times as potent (ED50 = 27.35 mg/kg, p.o.) in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number6318-41-8
      Chemical formulaC₁₁H₇NO₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (40 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesFerrandi, C., et al. 2007. J. Pharmacol. Exp. Ther. 322, 923.