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521236 PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

The PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 controls the biological activity of PDGFR/VEGFR2 Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, PDGFR Tyrosine Kinase Inhibitor XV, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      251356-32-8C₁₈H₁₇BrN₂O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668 (Cat. No. 521235) that is equally potent as SU6668 in inhibiting PDGFR (IC50 = 60 nM against PDGFRβ), while exhibiting more enhanced activity against VEGFR2 and FGFR1 (IC50 = 1.73 and 2.05 µM, respectively) in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ, but is of little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.
      Catalogue Number521236
      Brand Family Calbiochem®
      Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, PDGFR Tyrosine Kinase Inhibitor XV, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI
      References
      ReferencesSun, L. et al. 1999. J. Med. Chem. 42, 5120.
      Product Information
      CAS number251356-32-8
      FormOrange solid
      Hill FormulaC₁₈H₁₇BrN₂O₃
      Chemical formulaC₁₈H₁₇BrN₂O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      521236 0

      Documentation

      PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      521236

      Literatur

      Übersicht
      Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-May-2011 RFH
      Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, PDGFR Tyrosine Kinase Inhibitor XV, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI
      DescriptionA cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668 (Cat. No. 521235) that is equally potent as SU6668 in inhibiting PDGFR (IC50 = 60 nM against PDGFRβ), while exhibiting more enhanced activity against VEGFR2 and FGFR1 (IC50 = 1.73 and 2.05 µM, respectively) in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ, but is of little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number251356-32-8
      Chemical formulaC₁₈H₁₇BrN₂O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesSun, L. et al. 1999. J. Med. Chem. 42, 5120.