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513024 PD 151746 - CAS 179461-52-0 - Calbiochem

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain.

PD 151746 - CAS 179461-52-0 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid

Primary Target: calpain-1
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      179461-52-0C₁₁H₈FNO₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.
      Catalogue Number513024
      Brand Family Calbiochem®
      Synonyms3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
      References
      ReferencesSquier, M.K., et al. 1999. J. Cell Physiol. 178, 311.
      Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
      Product Information
      CAS number179461-52-0
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₁₁H₈FNO₂
      Chemical formulaC₁₁H₈FNO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain-1
      Primary Target K<sub>i</sub>260 nM against calpain-1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      513024 0

      Documentation

      PD 151746 - CAS 179461-52-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      PD 151746 - CAS 179461-52-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      513024

      Literatur

      Übersicht
      Squier, M.K., et al. 1999. J. Cell Physiol. 178, 311.
      Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.

      Literaturstellen

      Titel
    • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2011 RFH
      Synonyms3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
      DescriptionA cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for µ-calpain (Calpain I) over m-calpain (Calpain II) (Ki values, 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide induced apoptosis.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number179461-52-0
      Chemical formulaC₁₁H₈FNO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesSquier, M.K., et al. 1999. J. Cell Physiol. 178, 311.
      Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
      Citation
    • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
      		•