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496150 Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem

The Omi/HtrA2 Protease Inhibitor, Ucf-101, also referenced under CAS 313649-08-0, controls the biological activity of Omi/HtrA2 Protease. This small molecule/inhibitor is primarily used for Cancer applications.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: High Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid

Primary Target: pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      313649-08-0C₂₇H₁₇N₃O₅S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 µM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.
      Catalogue Number496150
      Brand Family Calbiochem®
      SynonymsHigh Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid
      References
      ReferencesCilenti, L., et al. 2003. J. Biol. Chem. 278, 11489.
      Product Information
      CAS number313649-08-0
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₂₇H₁₇N₃O₅S
      Chemical formulaC₂₇H₁₇N₃O₅S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetpro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      496150 0

      Documentation

      Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      496150

      Literatur

      Übersicht
      Cilenti, L., et al. 2003. J. Biol. Chem. 278, 11489.

      Broschüre

      Titel
      Caspases and other Apoptosis Related Tools Brochure
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      SynonymsHigh Temperature Requirement A2 Inhibitor I, 5-[5-(2-Nitrophenyl)furfurylidine]-1,3-diphenyl-2-thiobarbituric Acid
      DescriptionA cell-permeable, furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease, Omi/HtrA2 (IC50 = 9.5 µM for His-Omi134-458). Reported to inhibit Omi/HtrA2-induced cell death in caspase-9 (-/-) null fibroblasts. Does not significantly inhibit other serine proteases, including kallikrein, trypsin, plasmin, thrombin, and tissue plasminogen activator (t-PA) (IC50 ≥200 µM).
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number313649-08-0
      Chemical formulaC₂₇H₁₇N₃O₅S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCilenti, L., et al. 2003. J. Biol. Chem. 278, 11489.