530351 Sigma-AldrichNrf2 Activator IV, VSC2 - CAS 1554271-18-9 - Calbiochem
A cell-permeable, potent Nrf-2 activator that stimulates HO-1 expression in murine microglial BV-2 cultures. Induces overall Nrf2 cellular accumulation and nuclear translocation.
More>> A cell-permeable, potent Nrf-2 activator that stimulates HO-1 expression in murine microglial BV-2 cultures. Induces overall Nrf2 cellular accumulation and nuclear translocation. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: (E)-1-Chloro-2-(2-(2-methoxyphenylsulfonyl)vinyl)benzene, Nuclear Factor E2-related Factor 2 Activator IV, VSC2
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 1554271-18-9 | C₁₅H₁₃ClO₃S |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 5.30351.0001 |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable vinylsulfone that acts as a more potent Nrf-2 activator than the chalcones (e.g. Cat. No. 492040) in stimulating HO-1 expression in murine microglial BV-2 cultures (3.82-fold of control in 24 h; 20 µM). Shown to induce overall Nrf2 cellular accumulation & nuclear translocation (1 to10 µM) in murine dopaminergic CATH.a cultures, presumably by freeing Nrf2 from its negative regulator keap1, with concomitant upregulation of Nrf2-regulated antioxidant enzymes expression, effectively protecting CATH.a against BH4 toxicity (effective conc. 0.1 to 1.0 µM against 200 µM BH4; 24 h) in vitro and preventing MPTP- (Cat. No. 506382) induced motor dysfunctions and neurodegeneration in a murine PD model in vivo (3X 10 mg drug/kg/d p.o.; 4X 20 mg MPTP/kg/2 h i.p.). |
| Catalogue Number | 530351 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-1-Chloro-2-(2-(2-methoxyphenylsulfonyl)vinyl)benzene, Nuclear Factor E2-related Factor 2 Activator IV, VSC2 |
| References | |
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| References | Lee, J.A., et al. 2015. Br. J. Pharmacol. 172, 1087. Woo, S.Y., et al. 2014. J. Med. Chem. 57, 1473. |
| Product Information | |
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| CAS number | 1554271-18-9 |
| Form | Off-white solid |
| Hill Formula | C₁₅H₁₃ClO₃S |
| Chemical formula | C₁₅H₁₃ClO₃S |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5.30351.0001 | 04055977260731 |
Documentation
Nrf2 Activator IV, VSC2 - CAS 1554271-18-9 - Calbiochem SDB
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Nrf2 Activator IV, VSC2 - CAS 1554271-18-9 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 530351 |
Literatur
| Übersicht |
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| Lee, J.A., et al. 2015. Br. J. Pharmacol. 172, 1087. Woo, S.Y., et al. 2014. J. Med. Chem. 57, 1473. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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