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481990 Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem

Nigericin, Sodium Salt, Streptomyces hygroscopicus, CAS 28643-80-3, is an antibiotic K+ ionophore that disrupts the membrane potential and stimulates ATPase activity in mitochondria.

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Synonyme: Antibiotic K178

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      28643-80-3C₄₀H₆₇O₁₁ . Na
      Description
      OverviewDisrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+.
      Catalogue Number481990
      Brand Family Calbiochem®
      SynonymsAntibiotic K178
      References
      ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
      Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
      Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
      Product Information
      CAS number28643-80-3
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₄₀H₆₇O₁₁ . Na
      Chemical formulaC₄₀H₆₇O₁₁ . Na
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNigericin, Sodium Salt, Streptomyces hygroscopicus, CAS 28643-80-3, is an antibiotic K+ ionophore that disrupts the membrane potential and stimulates ATPase activity in mitochondria.
      Biological Information
      Primary TargetDisrupts the membrane potential and stimulates ATPase activity in mitochondria.
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQT6825000
      Safety Information
      R PhraseR: 23/24/25-36/37/38

      Toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      481990 0

      Documentation

      Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      481990

      Literatur

      Übersicht
      Moriyama, Y., et al. 1994. J. Biochem. 115, 213.
      Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
      Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      SynonymsAntibiotic K178
      DescriptionA monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
      FormLyophilized
      CAS number28643-80-3
      RTECSQT6825000
      Chemical formulaC₄₀H₆₇O₁₁ . Na
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityCHCl₃, ethanol, or ethyl acetate
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
      Toxicity Toxic
      Merck USA index14, 6541
      ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
      Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
      Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.