532336 Sigma-AldrichNOX Inhibitor VIII, VAS3947 - CAS 869853-70-3 - Calbiochem
VAS3947, NOXi
More>> VAS3947, NOXi Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole, NADPH Oxidase Inhibitor VIII, VAS-3947
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 869853-70-3 | C₁₄H₁₀N₆OS |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 5.32336.0001 |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable triazolo-pyrimidine derivative of VAS2870 (Cat. No. 492000) that displays enhanced solubility and acts as a selective inhibitor NOX family of NADPH oxidase. Shown to inhibit NOX activity in CaCo-2 cells (expressing NOX 1, 2, 4, and 5; IC50 = 12 µM), HL-60 cells (mainly expressing NOX2; IC50 = 2 µM), and A7r5 cells (mainly expressing NOX3 and 4; IC50 = 13 µM). Does not affect the activities of xanthine oxidase and endothelial nitric oxide synthase (eNOS) even at higher concentrations (~100 µM). Acts synergistically with Imatinib (Cat. No. 504595) to reduce the proliferation of chronic myeloid leukemia (CML) cells. Please note that the molecular weight for this compound is batch-specific due to variable water content. |
| Catalogue Number | 532336 |
| Brand Family | Calbiochem® |
| Synonyms | 3-Benzyl-7-(1,3-oxazol-2-ylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)oxazole, NADPH Oxidase Inhibitor VIII, VAS-3947 |
| References | |
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| References | Sanchez-Sanchez, B., et al. 2014. Clin. Cancer Res. 20, 4014. Altenhofer, S., et al., 2012. Cell. Mol. Life Sci. 69, 2327. Wind, S., et al. 2010. Br. J. Pharmacol. 161, 885. |
| Product Information | |
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| CAS number | 869853-70-3 |
| Form | Light yellow solid |
| Hill Formula | C₁₄H₁₀N₆OS |
| Chemical formula | C₁₄H₁₀N₆OS |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | NADPH Oxidase |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5.32336.0001 | 04055977260069 |
Documentation
NOX Inhibitor VIII, VAS3947 - CAS 869853-70-3 - Calbiochem SDB
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Literatur
| Übersicht |
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| Sanchez-Sanchez, B., et al. 2014. Clin. Cancer Res. 20, 4014. Altenhofer, S., et al., 2012. Cell. Mol. Life Sci. 69, 2327. Wind, S., et al. 2010. Br. J. Pharmacol. 161, 885. |
Broschüre
| Titel |
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| NPI Flyer- Epigenetics and Nuclear Function Feature |
| New Products - Antibodies, Small Molecule, Inhibitors |
| Pathways and Biomarkers of Oxidative Stress |
Technische Informationen
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| White Paper: Further considerations of antibody validation and usage. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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