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505764 NMDA Antagonist XI, N1-dansyl-spermine - Calbiochem

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Synonyme: NMDA channel blocker, N1-dansyl-spermine, N1-DnsSpm

Primary Target: NMDA
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505764
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₃₇N₅O₂S•3HCl

Preis & Verfügbarkeit

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5.05764.0001
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      		 Glasflasche 10 mg
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      Description
      OverviewAn N-sulfonyl-polyamine that acts as a potent and more specific antagonist of NMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340 nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13 µM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58 µM) and diminishes the induction of ornithine decarboxylase. At higher concentration (˜100 µM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices.
      Catalogue Number505764
      Brand Family Calbiochem®
      SynonymsNMDA channel blocker, N1-dansyl-spermine, N1-DnsSpm
      References
      ReferencesKirby, B.P., et al. 2005, Eur. J. Pharmacol. 524, 53.
      Li, J., et al. 2005, Brain Res. 1055, 180.
      Kirby, B. et al. 2004, Brain Res. 1011, 69.
      Seiler, N., et al. 1998, J. Biochem. Cell Biol. 30, 393.
      Chao, J., et al. 1997, Mol. Pharm. 51, 861.
      Product Information
      FormYellowish-white powder
      Hill Formula C₂₂H₃₇N₅O₂S•3HCl
      Chemical formulaC₂₂H₃₇N₅O₂S•3HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA
      Primary Target IC<sub>50</sub>0.31 µ
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.05764.0001 04055977243543

      Documentation

      NMDA Antagonist XI, N1-dansyl-spermine - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Kirby, B.P., et al. 2005, Eur. J. Pharmacol. 524, 53.
      Li, J., et al. 2005, Brain Res. 1055, 180.
      Kirby, B. et al. 2004, Brain Res. 1011, 69.
      Seiler, N., et al. 1998, J. Biochem. Cell Biol. 30, 393.
      Chao, J., et al. 1997, Mol. Pharm. 51, 861.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-October-2013 JSW
      SynonymsNMDA channel blocker, N1-dansyl-spermine, N1-DnsSpm
      DescriptionAn N-sulfonyl-polyamine that acts as a potent and more specific antagonist of NMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340 nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13 µM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58 µM) and diminishes the induction of ornithine decarboxylase. At higher concentration (˜100 µM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices.
      FormYellowish-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₃₇N₅O₂S•3HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKirby, B.P., et al. 2005, Eur. J. Pharmacol. 524, 53.
      Li, J., et al. 2005, Brain Res. 1055, 180.
      Kirby, B. et al. 2004, Brain Res. 1011, 69.
      Seiler, N., et al. 1998, J. Biochem. Cell Biol. 30, 393.
      Chao, J., et al. 1997, Mol. Pharm. 51, 861.