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GF041 Monocyte Chemotactic Protein-1, Recombinant rat

The Macrophage/monocyte chemoattractant protein-1 (or MCP-1 protein) plays an important role in the inflammatory response of blood monocytes & tissue macrophages.

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Key Applications: Cell Culture UniProt Number: P13500 Entrez Gene Number: NM_002982.3
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GF041
10 µg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesSourcePurity
      CULTRat E.coliGreater than 98% by SDS-PAGE analysis and HPLC analysis.
      Description
      Catalogue NumberGF041
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMonocyte Chemotactic Protein-1, Recombinant rat
      OverviewMacrophage/monocyte chemoattractant protein-1 (MCP-1) plays an important role in the inflammatory response of blood monocytes and tissue macrophages. Rat MCP-1 is a 14.1 kDa protein containing 125 amino acid residues.
      Alternate Names
      • MCP-1
      References
      Product Information
      PresentationLyophilized protein with no additives. The protein may appear as a haze or film which is difficult to see at the bottom of the vial.
      Quality LevelMQ100
      Applications
      ApplicationThe Macrophage/monocyte chemoattractant protein-1 (or MCP-1 protein) plays an important role in the inflammatory response of blood monocytes & tissue macrophages.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 98% by SDS-PAGE analysis and HPLC analysis.
      SourceE.coli
      Specific ActivityDetermined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
      Gene Symbol
      • CCL2
      • SMC-CF
      • MCAF
      • HSMCR30
      • GDCF-2
      • SCYA2
      • MCP1
      • HC11
      • MGC9434
      • MCP-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P13500 # Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
      SIZE: 99 amino acids; 11025 Da
      SUBUNIT: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.
      SUBCELLULAR LOCATION: Secreted.
      PTM: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
      SIMILARITY: SwissProt: P13500 ## Belongs to the intercrine beta (chemokine CC) family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4°C for one week or -20°C for future use. After reconstitution store in working aliquots at -20°C for up to 6 months.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      GF041 04053252678448

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      Kategorien

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors