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533998 Mitotic Tracker Probe, CDy6 - Calbiochem

A cell-permeable, photostable fluorescent probe for real-time imaging of lysosomal dynamics in proliferating cells undergoing mitosis.

Mitotic Tracker Probe, CDy6 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: (E)-7-(3,5-di-tert-Butyl-2-methoxystyryl)-3-(3-(2-(dimethylamino)ethylamino)-3-oxopropyl)-5,5-difluoro-9-methyl-5H-dipyrrolo[1,2-c:1ʹ,2ʹ-f][1,3,2]diazaborinin-4-ium-5-uide, Lysosomal Tracker Probe, CDy6

533998
  
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₃₄H₄₇BF₂N₄O₂
      Description
      OverviewA cell-permeable, photostable, bodipy-derived fluorescent probe that can be used for real-time imaging of lysosomal dynamics in proliferating cells undergoing mitosis. Undergoes rapid re-localization from cytoplasm to nucleus during cell division, but does not interfere with cell cycle. Displays a sharp increase in intensity during mitosis and its fluorescence displays high sensitivity to acidic environment (pH 2-4). Can also be used for time-dependent whole-body in vivo imaging of tumor xenografts (CDy6 stained HeLa cells, s.c.) in BALB/c nude mice up to 21 days. Exhibits greater brightness, higher photostability, and significantly reduced toxicity when compared to LysoTracker Red, LysoTracker Green, LysoSensor Green and HOE33342. Abs max: 570 nm; Em max: 585 with a quantum yield of 0.89.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533998
      Brand Family Calbiochem®
      Synonyms(E)-7-(3,5-di-tert-Butyl-2-methoxystyryl)-3-(3-(2-(dimethylamino)ethylamino)-3-oxopropyl)-5,5-difluoro-9-methyl-5H-dipyrrolo[1,2-c:1ʹ,2ʹ-f][1,3,2]diazaborinin-4-ium-5-uide, Lysosomal Tracker Probe, CDy6
      References
      ReferencesJeong, Y.M., et al. 2015. Chem. Biol. 22, 299.
      Product Information
      FormDark purple powder
      Hill FormulaC₃₄H₄₇BF₂N₄O₂
      Chemical formulaC₃₄H₄₇BF₂N₄O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcytoplasm
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Emission max.
      Excitation max.
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C). Store in a dark vial, protected from light.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      533998 0

      Documentation

      Mitotic Tracker Probe, CDy6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Jeong, Y.M., et al. 2015. Chem. Biol. 22, 299.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-December-2016 JSW
      Synonyms(E)-7-(3,5-di-tert-Butyl-2-methoxystyryl)-3-(3-(2-(dimethylamino)ethylamino)-3-oxopropyl)-5,5-difluoro-9-methyl-5H-dipyrrolo[1,2-c:1ʹ,2ʹ-f][1,3,2]diazaborinin-4-ium-5-uide, Lysosomal Tracker Probe, CDy6
      DescriptionA cell-permeable, photostable, bodipy-derived fluorescent probe that can be used for real-time imaging of lysosomal dynamics in proliferating cells undergoing mitosis. Undergoes rapid re-localization from cytoplasm to nucleus during cell division, but does not interfere with cell cycle. Displays a sharp increase in intensity during mitosis and its fluorescence displays high sensitivity to acidic environment (pH 2-4). Can also be used for time-dependent whole-body in vivo imaging of tumor xenografts (CDy6 stained HeLa cells, s.c.) in BALB/c nude mice up to 21 days. Exhibits greater brightness, higher photostability, and significantly reduced toxicity when compared to LysoTracker Red, LysoTracker Green, LysoSensor Green and HOE33342. Abs max: 570 nm; Em max: 585 with a quantum yield of 0.89.
      FormDark purple powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₄H₄₇BF₂N₄O₂
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Use only fresh, anhydrous DMSO for reconstitution.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C). Store in a dark vial, protected from light.
      Toxicity Standard Handling
      ReferencesJeong, Y.M., et al. 2015. Chem. Biol. 22, 299.