Millipore Sigma Vibrant Logo

504817 Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023

Primary Target: mitochondria
View Products on Sigmaaldrich.com
504817
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
56396-35-1C₁₈H₁₂N₂O₂

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
5.04817.0001
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Glasflasche 5 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      5.04817.0002
      Verfügbarkeit wird abgerufen...
      —
      Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
      Lieferbar 
      Produkt wurde eingestellt
      Begrenzter Lagerbestand
      Bestätigung der Verfügbarkeit erforderlich
        Restmenge: Angebot folgt
          Restmenge: Angebot folgt
          Bitte erfragen
          Kontakt zum Kundenservice
          Contact Customer Service

          		 Glasflasche 25 mg
          Preis wird abgerufen...
          Preis nicht abrufbar
          Die Mindestmenge muss ein Vielfaches sein von
          Maximum Quantity is
          Bei Bestätigung Weitere Informationen
          Sie haben () gespart
           
          —
          Bitte erfragen
          		 —
          Description
          OverviewA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
          Catalogue Number504817
          Brand Family Calbiochem®
          Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
          References
          ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
          Bricker, D.K., et al. 2012. Science 337, 96.
          Herzig, S., et al. 2012. Science 337, 93.
          Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
          Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
          Halestrap, A.P. 1978. Biochem. J. 172, 377.
          Halestrap, A.P. 1975. Biochem. J. 145, 85.
          Product Information
          CAS number56396-35-1
          FormBright yellow solid
          Hill FormulaC₁₈H₁₂N₂O₂
          Chemical formulaC₁₈H₁₂N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetmitochondria
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Bestellnummer GTIN
          5.04817.0001 04055977244199
          5.04817.0002 04055977244205

          Documentation

          Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem SDB

          Titel

          Sicherheitsdatenblatt (SDB) 

          Literatur

          Übersicht
          Divakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
          Bricker, D.K., et al. 2012. Science 337, 96.
          Herzig, S., et al. 2012. Science 337, 93.
          Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
          Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
          Halestrap, A.P. 1978. Biochem. J. 172, 377.
          Halestrap, A.P. 1975. Biochem. J. 145, 85.
          Datenblatt

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
          DescriptionA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
          FormBright yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number56396-35-1
          Chemical formulaC₁₈H₁₂N₂O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
          Toxicity Standard Handling
          ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
          Bricker, D.K., et al. 2012. Science 337, 96.
          Herzig, S., et al. 2012. Science 337, 93.
          Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
          Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
          Halestrap, A.P. 1978. Biochem. J. 172, 377.
          Halestrap, A.P. 1975. Biochem. J. 145, 85.