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505984 Mitochondrial Content Inducer, BRD6897 - CAS 618395-82-7 - Calbiochem

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Synonyme: BRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one

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505984
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
618395-82-7C₂₅H₂₁N₃O₂S₂

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      		 Glasflasche 25 mg
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      Description
      OverviewA cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (~10 µM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (~50% increase in 3T3-L1 and HUVEC at 10 µM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.
      Catalogue Number505984
      Brand Family Calbiochem®
      SynonymsBRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one
      References
      ReferencesKitami, T., et al. 2012. PLoS ONE 7, e33755.
      Product Information
      CAS number618395-82-7
      FormOff-white powder
      Hill FormulaC₂₅H₂₁N₃O₂S₂
      Chemical formulaC₂₅H₂₁N₃O₂S₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.05984.0001 04055977262568

      Documentation

      Mitochondrial Content Inducer, BRD6897 - CAS 618395-82-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Kitami, T., et al. 2012. PLoS ONE 7, e33755.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-November-2013 JSW
      SynonymsBRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one
      DescriptionA cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (~10 µM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (~50% increase in 3T3-L1 and HUVEC at 10 µM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number618395-82-7
      Chemical formulaC₂₅H₂₁N₃O₂S₂
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKitami, T., et al. 2012. PLoS ONE 7, e33755.