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14-728M Mer Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human Mer, amino acids 557-882, for use in Kinase Assays.

Mer Protein, active, 250 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-728M
250 µg  Also available in 10 μg size (cat#14-728) and in bulk (cat# 14-728-K).
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-728M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMer Protein, active, 250 µg
      OverviewN-terminal GST-tagged, recombinant, human Mer, amino acids 557-882
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST-tagged, recombinant, human Mer, amino acids 557-882, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
      Gene Symbol
      • MERTK
      • MGC133349
      • c-mer
      • mer
      • MER
      • MER-PEN
      Protein TargetMer
      Purification MethodGlutathione-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummarySIZE: 999 amino acids; 110249 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
      TISSUE SPECIFICITY: Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
      DISEASE: SwissProt: Q12866 # Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
      SIMILARITY: SwissProt: Q12866 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight64.4kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDI
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-728) and in bulk (cat# 14-728-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-728M 04053252506321

      Verwandte Produkte & Anwendungen

      Alternative Packsize

      Bestellnummer Beschreibung  
      14-728 Mer Protein, active, 10 µg Preis & Verfügbarkeit

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      Kategorien

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases